So, I did a fresh install and re-install on this old Optiplex 360 here at work and couldn’t figure out why PS wasn’t running. Some of the suite would open up, but PS and Illustrator were having issues (didn’t check them all).
Strangest fix apparently. I thought Photoshop was hanging (not responding), but it actually was running.
So for the fix. This system had both monitors rotated 90 degrees and apparently that was the issue. When I put the main display back to normal, it was fine.
Go figure. One of those weird things…
(If anyone cares for the specifics of the issue:
GeForce 9300 GE
2x Dell 1908FP-BLK)